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Methyl gallate

Name: Methyl gallate
Brand: TargetMol
SKU: T3730
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3730Cas No. 99-24-1

Alias NSC 363001, Gallincin, Gallicin, Gallic acid methyl ester

Methyl gallate (Gallincin) is a reverse transcriptase inhibitor with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibition activities.

Methyl gallate

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Purity: 99.88%

Catalog No. T3730Alias NSC 363001, Gallincin, Gallicin, Gallic acid methyl esterCas No. 99-24-1

Methyl gallate (Gallincin) is a reverse transcriptase inhibitor with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibition activities.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

Appearance:Solid

Color:White

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COA HNMR HPLC LCMS

Product Introduction

Methyl gallate AI Summary

Methyl gallate exhibits a multifaceted bioactivity profile across several biological systems and assays. It shows inhibitory activity against Catechol-O-methyltransferase (COMT) from porcine liver with a Km value of 25500.0 nM, indicating potential effects on catecholamine metabolism. It promotes [1-3H]-2-deoxy-D-glucose uptake in 3T3 L1 adipocytes with an activity level of 20.0 Bq and has DPPH radical scavenging activity in liposome and ethanol solution assays, with IC50 values of 8400.0 nM and 7200.0 nM, respectively. Methyl gallate demonstrates antimicrobial activity against various dermatophyte fungi with a minimum inhibitory concentration (MIC) of 100.0 ug/mL. However, its efficacy is lower against Candida species, Saccharomyces cerevisiae, Cryptococcus neoformans, and certain molds, with MIC values above 250.0 ug/mL. It also shows ABTS radical scavenging activity, xanthine oxidase inhibition (IC50 = 15520.0 nM), and HIV1 recombinant integrase inhibition (IC50 = 28.5 ug/mL). The compound has antiprotozoal activity against Giardia lamblia and Entamoeba histolytica, with IC50 values of 49.2 ug/mL and 143.6 ug/mL, respectively. Additionally, it exhibits antifeedant activity against Hylobius abietis, antifungal activity against Saccharomyces cerevisiae (MIC > 3200.0 ug/mL), antiinflammatory activity in mouse RAW264.7 cells (IC50 values of 11,100.0 nM for nitric oxide production and 29,400.0 nM for TNF-alpha secretion), and cytotoxicity against human HeLa cells with an IC50 value of 267200.0 nM. Methyl gallate also inhibits FucT-7 (IC50 = 8000.0 nM), exhibits anti-platelet activity in rat platelet-rich plasma, and demonstrates various inhibitor activities against enzymes and proteins such as Lamin A splicing, Human Jumonji Domain Containing 2E, Tyrosyl-DNA Phosphodiesterase, Bacillus subtilis Sfp phosphopantetheinyl transferase, and more, with potencies ranging from 1258.9 nM to 94266.0 nM. Additionally, it shows cytotoxicity against mouse and human cell lines and has anticomplement activity in sheep and rabbit erythrocytes. Overall, Methyl gallate is characterized by diverse bioactivity, including antioxidant, antimicrobial, antiprotozoal, antiviral, anti-inflammatory, cytotoxic, and enzyme inhibitory properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Methyl gallate (Gallincin) is a reverse transcriptase inhibitor with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibition activities.
Synonyms	NSC 363001, Gallincin, Gallicin, Gallic acid methyl ester

Chemical Properties

Molecular Weight	184.15
Formula	C₈H₈O₅
Cas No.	99-24-1
Smiles	C(OC)(=O)C1=CC(O)=C(O)C(O)=C1
Relative Density.	1.501g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (271.52 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.86 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4304 mL	27.1518 mL	54.3036 mL	271.5178 mL
5 mM	1.0861 mL	5.4304 mL	10.8607 mL	54.3036 mL
10 mM	0.5430 mL	2.7152 mL	5.4304 mL	27.1518 mL
20 mM	0.2715 mL	1.3576 mL	2.7152 mL	13.5759 mL
50 mM	0.1086 mL	0.5430 mL	1.0861 mL	5.4304 mL
100 mM	0.0543 mL	0.2715 mL	0.5430 mL	2.7152 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc